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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Faculty of Theology hosts annual meeting of Society for Practical Theology
2015-01-30

From the left are: Prof Yolanda Dreyer (Chairperson of SPTSA, University of Pretoria), Prof Johann Rossouw (UFS), Prof Hussein Solomon (UFS) and Prof Johan Cilliers (Stellenbosch University).
Photo: Michelle Nothling

The privilege of hosting the annual meeting of the Society for Practical Theology in South Africa (SPTSA) fell to the University of the Free State (UFS) this year. Delegates from across the country recently convened on the Bloemfontein Campus to attend the event from 21 – 23 January 2015.

The three-day congress saw several high-profile keynote speakers discussing the topic of ‘Power of religion and religions of power’.

Dr Johann Rossouw from the UFS Department of Philosophy presented a paper on ‘Power, the state and the church in South Africa’. Dr Rossouw regards the cooperation between theologians and philosophers as integral to help us understand the time we live in. Twenty years since the dawn of South Africa’s democracy, “the gap between the country we were promised and the country we received is bigger than ever,” Dr Rossouw said. “A South-African Church … cannot but make her voice heard regarding this gap.”

Expert on conflict resolution and fundamentalism, Prof Hussein Solomon from the UFS Department of Political Studies and Governance scrutinised the compatibility of Islam with democracy. He warned, though, against “the labelling of a conflict as religious on the mere basis of its religious overtones.” Prof Solomon’s paper, ‘Political Islam: trends, trajectory and future prospects,’ not only advocated tolerance and political pluralism, but also pointed to the fact that it is “in the common good of all humanity” to avert a “Clash of Civilizations”.

‘God in granite?’ – Prof Johan Cilliers’ paper – investigated the phenomenon of the monumentalization of religion. Prof Cilliers from Stellenbosch University explained that monuments often have “spiritual character and iconic value, in the sense that it offers a space for the formation or discovery of meaning.” In his presentation he showed, though, that monuments – even those connected to religious motifs – “seldom escape the lure of power”.

The event was organised by the University of the Free State’s Faculty of Theology, Department of Practical Theology.

  

For more information or enquiries contact news@ufs.ac.za .

 

 

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