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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

UFS implements B Ed degree on Qwaqwa campus

2006-11-09

The University of the Free State has taken a step to address the need of black teachers in the country by offering a B Ed degree in the further education and training (FET) phase at its Qwaqwa Campus as from January 2007.

“The accredited B Ed qualification provides the opportunity to students to empower themselves to become professional teachers in secondary schools. It is also suitable for the training of expertise for education-related careers such as instructors and trainers,” said Dr Elias Malete, acting principal of the UFS Qwaqwa Campus.

According to Dr Malete, education in South Africa is heading for a disaster owing to the large-scale exodus of teachers combined with the low enrolment figures of prospective teachers.

“Approximately 19 000 teachers leave the teaching profession annually, while all the training institutions in the country only manage to produce 4 800 new entrants to the profession,” said Dr Malete.

“Indications are that a considerable number of students, especially from KwaZulu-Natal, want to study education at the Qwaqwa Campus. The implementation of the course will also address the need for qualified teachers in the country and contribute to the sustainability of the campus,” said Dr Malete.

“The duration of the B Ed is four years. Prospective students who do not meet the admission requirements may enroll for a one-year career preparation programme and successful completion will provide them with admission to the degree the following year. Prospective students with an M-score of 24-27 may enroll for an extended B Ed programme over a period of five years,” said Dr Malete.

Other education programmes that are offered at the Qwaqwa Campus include a B Ed Honors degree in Curriculum Studies, a B Ed Honors degree in Education Management and Leadership and a Postgraduate Certificate in Education (PGCE).

Prospective students may call (058) 718-5000 or visit the UFS web site at www.ufs.ac.za for more information. Applications for admission to this programme close on 30 November 2006.

Media release

Issued by: Lacea Loader

Media Representative

Tel: (051) 401-2584

Cell: 083 645 2454

E-mail: loaderl.stg@mail.uovs.ac.za

8 November 2006

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