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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

First-years at South Campus step into a bright future
2015-02-05

Photo: Stefan Lotter

This is the first step to a bright future.

This was the resounding message that welcomed first-year students to the South Campus. “Remember,” Tshegofatso Setilo, Manager of the University Preparation Programme said, “a journey of a thousand miles begins with the first step.” But please do not get discouraged on your way, she urged, because “this is your first step to a bright future.

In his welcoming message, Prof Nicky Morgan, Vice-Rector: Operations at the UFS referred to the South Campus as the giant of the south. “This is one of the trailblazing campuses of the university,” he said. “No doubt what you’ll experience on this campus, you’ll never forget.”

This year, the South Campus boasts with 1 200 first-year students taking part in our University Preparation and Extended Programmes. These programmes allow students – whose matric marks did not reach the required total – the opportunity to study at the University of the Free State (UFS). The result? An astounding rise in pass rates. Some of the students on the South Campus outperform their peers studying at the Bloemfontein Campus, Prof Morgan remarked.

“You’ve got it in yourself. You’ve got the potential to unleash yourself on the world,” Prof Morgan said. You do not always realise the value of something that has come your way, he said. So, every moment you get an opportunity, he advised, use it to shape your future.

Addressing the newcomers’ fears, Prof Morgan urged each student to open themselves to the good and new experiences waiting for them. “When you find yourself in a new space, it always begins with you,” he said. Learn to understand how to live in harmony in different spaces.

Prof Morgan placed great emphasis on his closing remark: “At university, the more questions you seek to have answered – they’re worth more than the answers you have.”

 

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