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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Four Kovsies play in the Chile/Belgium series
2015-02-10

Nicole Walraven, Lethabo Maebana (SRC: Media and Marketing), Tanya Britz, Kerry-beth Berry (SRC: Day- and Commuting Students), Cornelle Botha, Liné Malan, and Dominique De Gouveia (SRC: Sport)

Tanya Britz, Nicole Walraven, Cormelle Botha, and Liné Malan turned out for the Protea hockey team in the two series against Chile and Belgium in Cape Town from 22 January to 2 February.

Britz has been playing for the senior Protea team since her matric year at Sentraal High School, but for Walraven, Botha, and Malan this series marked their debut for the senior national hockey team. The series against Chile and Belgium both ended in draws for the Protea women’s team.

Shortly before the end of the series against Belgium, the three Kovsies making their debut for the senior national hockey team had the following to say to the Volksblad:

“It was unbelievably inspiring to stand next to these incredible players wearing the Green and Gold and to sing the national anthem in front of a home crowd. It was worth all the hard work and dedication. The support and acceptance of my team mates helped calm my nerves when the whistle blew. It was such an honour – it still feels like a dream. (Nicole Walraven)

“It is an indescribable feeling, something that I dreamt about for years. The nerves niggled before the game, but it was such a huge privilege and honour to play in the Protea colours.” (Cornelle Botha)

“It’s difficult to describe the feeling a person experiences when you sing the national anthem wearing the Green and Gold. It was a feeling of pride; the accompanying excitement felt as if I had a thousand butterflies in my stomach. It’s a moment I shall never forget and a dream come true.” (Liné Malan)

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