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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

UFS takes further steps to address load shedding
2015-02-24

The South African economy is experiencing its worst electricity crisis since 2008, with state power firm Eskom implementing load shedding as it struggles to meet growing demand for power.

The University of the Free State (UFS) has been planning and implementing projects to reduce the impact of load shedding since 2008. This was done primarily to ensure that the academic programme does not suffer as a result of the increasing cuts in power supply, which continued this year.

The university’s main concern is the supply of emergency power to lecture halls and laboratories.

Up to date, 35 generators are serving 55 buildings on the three campuses of the UFS. This includes 26 generators on the Bloemfontein Campus, eight on the Qwaqwa Campus in the Eastern Free State and one generator on the South Campus in Bloemfontein. The generators are serviced regularly and kept in a working condition.

Since 2010, the university has also ensured that all new academic buildings being built were equipped with emergency power.

On the South Campus in Bloemfontein the new lecture hall building and the Computer Laboratory are equipped with emergency power, while the installation of emergency power generators in other buildings is underway. Most of the buildings on the Qwaqwa Campus in the Eastern Free State are provided with emergency power.

“To expand on the work that have already been done, the main objective in the installation of more generators on the Bloemfontein Campus will be to ensure that lecture halls with emergency power are available on the centrally booked timetables and that more of the critical laboratories are equipped with emergency power,” said Mr Nico Janse van Rensburg, Senior Director: University Estates.

“There are still some critical buildings and venues on the Bloemfontein Campus that must be equipped with emergency power. However, this is a costly process and will have to be phased in over a period of time. The further implementation of emergency power is dependent on delivery times of equipment. The university is also looking into alternative power supply solutions, such as solar power,” he said.

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