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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

UFS releases draft charter to accelerate transformation
2007-02-02

The University of the Free State (UFS) today released a draft Institutional Charter which is intended to enhance and accelerate the ongoing transformation of the institution towards a non-racial, non-sexist future.

Speaking at the official opening of the university today, the Rector and Vice-chancellor, Prof Frederick Fourie, said the draft Institutional Charter, was an important milestone in the transformation debate for the university and the country.

“The draft charter acknowledges that black people, women and people with disabilities have been marginalised from job and developmental opportunities, within the higher education sector and at this university,” Prof Fourie said.

The charter commits the university to meeting the challenges of a transforming higher education institution in a developing society, in particular the challenges of nation-building, reconciliation, redress, non-racialism and non-sexism – and ultimately normalisation – within a high-quality academic institution.

The principles of the draft charter firmly signal the university’s commitment to diversity – attaining and maintaining substantive and sufficient diversity (including multiculturalism and multilingualism) – in its quest for quality and excellence. 
Prof Fourie said the draft charter seeks to build consensus among staff and students at the UFS about the ultimate goals of transformation at a higher education institution.

The charter proposes several basic values and principles that should guide the transformation process and at the same time serve as a basis for a future, normalised university - a promised land to transform towards.

The discussion document says academic quality is intrinsically linked to transformation and it commits the university to strengthening the core competencies of research, teaching and learning as well as community service so as to ensure a robust university for future generations.

“Indeed the thousands of matriculants, black and white, who apply to study at the UFS want to study at a good university, and a good university wants to attract the best black and white students and the best black and white staff, male and female,“ Prof Fourie said.

He said the draft charter also seeks to safeguard academic freedom and institutional autonomy as the foundation of critical inquiry and scholarship.

Regarding the critical issue of creating a new institutional culture, the draft charter commits the UFS to creating a sense of belonging for all members of the university – black and white, male and female, of whatever language, religious, cultural or economic background, as well as people with disabilities.

Media release
Issued by: Lacea Loader
Media Representative
Tel:  (051) 401-2584
Cell:  083 645 2454
E-mail:  loaderl@mail.uovs.ac.za
02 February 2007

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