Latest News Archive

Please select Category, Year, and then Month to display items
Previous Archive
12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Forensic investigation at UFS Computer Services division in final stage of finalisation
2007-02-01

Statement by prof Niel Viljoen, Chief Director: Operations  
 
The case in which possible irregularities were investigated at the University of the Free State’s (UFS) Computer Services Division at the end of 2005, and which led to two Deputy Directors’ compulsory leave pending an investigation, is making good progress and is in the final stage of finalisation.
 
One of the Deputy Directors resigned unconditionally a day before his disciplinary hearing was to take place. He is one of two staff members who were placed on compulsory leave after an internal investigation ordered by the UFS management indicated possible irregularities in the division.
 
“As a result of the extent of the case and the involvement of more than one local business, the investigation had a long course,” said Prof Viljoen.
 
“The Deputy Director who resigned would have appeared before a disciplinary committee with Judge Joos Hefer as chairperson on charges of misconduct, involving more than R500 000,” said Prof Viljoen.
 
“We are going ahead with the process of criminal prosecution against this person and a docket was opened at the commerce branch of the South African Police Services (SAPS).  A civil action to recover damages from him was started,” Prof Viljoen said.
 
With a couple of exceptions, the internal disciplinary process of the other persons involved in the case is also finalised. “The disciplinary hearing of the Deputy Director, who is still in the service of the UFS’s Computer Services division, is scheduled for May 2007. This person is still on compulsory leave,” Prof Viljoen said.
 
“To demonstrate our commitment to the enhancement of honest work ethics and to give to personnel and students a mechanism to bring any unethical business practices to the attention of the UFS management, a fraud hotline was installed last year. The hotline is operated 24 hours a day for 365 days of the year by KPMG,” Prof Viljoen said.
 
Prof Viljoen thanked everyone who was involved in the investigation for their cooperation. This includes staff as well as people from outside the UFS.  “We are committed to transparent corporate management. Any possible irregularities will be investigated and if staff or students are found guilty of any irregular behaviour, strict actions would be taken against these persons,” Prof Viljoen said.
 
Media release
Issued by: Lacea Loader
Media Representative
Tel: (051) 401-2584
Cell: 083 645 2454
E-mail: loaderl@mail.ufs.ac.za
2 February 2007
 

 

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept