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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

UFS mourns the death of a great academic

2007-02-27

It is with great sadness that the management of the University of the Free State (UFS) heard of the death of Prof. Dawfré Roode.

Prof. Roode (70) was the first Registrar: Academics at the UFS. He retired in July 1997 and was living in Jeffrey’s Bay with his second wife, Daphne, for the past three years.

Prof Roode’s ties with the UFS stretch over more than fifty years. He registered at the UOFS in 1955 as first-year student and was elected as chairperson of the student representative council in 1958. He also represented the university on the cricket field and as Free State nineteen-year old in the Currie Cup. His academic career at the UOFS started in 1963 when he was appointed as lecturer in Sociology and Social Work. After completing his D Phil in 1964, he was promoted to senior lecturer in 1966. He became the first head of the Department of Sociology in 1972 and in 1989 he was appointed as Registrar: Academics and in 1989 Vice-Rector: Staff and Administration.

“Prof Roode brought professionalism to the administration that did not exist. He not only served the academe as registrar, but also established it as an important function within the UOFS. His ‘institutional memory’ about earlier decisions and events at the UOFS is also legendary,” said Prof Frederick Fourie, Rector and Vice-Chancellor at the UFS.

Prof Roode’s father, the late Prof Dawie Roode, was the first head of the Department of Music at the UFS. Prof Dawfré Roode had a love for music and was closely involved with the establishment of the Odeion String Quartet.

In October 2004 the university honoured him with a Centenary Medal for his outstanding leadership and contribution, as Registrar and Vice-Rector, to the development of the UFS by establishing and developing a strong and professional administrative structure at the UFS.

“Prof Roode left deep footprints at the UFS. I am glad that we could honour him for this in 2004 with a Centenary Medal before he passed away. He also attended the launch of the university’s history book earlier in February,” said Prof Fourie.

“Our sympathies go to Ms Trudie Roode (his first wife) and their three children Ms Frelet Roux and Gerda Daffue, and their son, Mr Dawie Roode. Prof Roode has left a gap in the hearts of the people who knew and worked with him at the UFS,” said Prof Fourie.

A memorial service will be held in Jeffrey’s Bay on Wednesday 28 February 2007 at 10:30. A memorial service will also be held in Bloemfontein on Wednesday 7 March 2007. More details will be made available at a later stage.

Media release
Issued by: Lacea Loader
Media Representative
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@mail.uovs.ac.za
27 February 2007

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