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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

UFS and Free State department of Agriculture take hands

2007-04-02

During the visit to the Faculty of Natural and Agricultural Sciences of the University of the Free State (UFS) were, from the left: Mr Casca Mokitlane (Member of the Executive Committee for Agriculture in the Free State), Prof. Herman van Schalkwyk (Dean of the Faculty of Natural and Agricultural Sciences at the UFS) and Mr Tshepiso Ramarakane (Head of the Department of Agriculture in the Free State).

Photo: Stephen Collett

There is a need for the University of the Free State (UFS) and the Free State Department of Agriculture to work together as partners to pursue the development of agriculture in the province.

Prof. Herman van Schalkwyk, Dean of the Faculty of Natural and Agricultural Sciences at the UFS and Mr Casca Mokitlane, Member of the Executive Council (MEC) in the Free State, recently held investigative discussions to determine how a more focused strategic leadership for the development of agriculture in the province can be established.

Mr Mokitlane visited the faculty on the Main Campus in Bloemfontein and exchanged information with Prof. Van Schalkwyk on development issues in agriculture. Certain important agricultural issues between the faculty and the department was identified in order to build a more vibrant and sustainable agricultural industry in the province.

A few issues that would contribute to the building of relationships for sectoral development such as agricultural research, the training of small farmers and the department’s guidance officers, the support of community projects and targets for the land reform process were also discussed.

Mr Mokitlane visited nine departments within the faculty, among others the Lengau Agricultural Training Centre, where he had short discussions with prospective black farmers.

According to Prof. Van Schalkwyk thorough training of black emerging farmers was discussed. It was clear to him that small farmers who have already completed their training are a priority for the faculty. Further discussions will continue at a later stage.

Mr Mokitlane was also informed about the research done at the faculty, training programmes offered and the roles the different divisions are playing in terms of community service. Postgraduate students informed the delegates of their specific research and studies.

“We have great appreciation for the time Mr Mokitlane and his colleagues from the Department of Agriculture spent listening to what the faculty can do for agriculture in the Free State and also the rest of the country,” said Prof. Van Schalkwyk.

“Both parties are in agreement that the one cannot function without the other. We must move closer to each other in the interest of agriculture to face the challenges ahead,” said Prof. Van Schalkwyk.

Media release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl@ufs.ac.za
30 March 2007

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