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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Prisca Odero awarded ASA Presidential Fellowship
2015-02-17

Dr Odero (on the right) pictured with Suzanne Baazet, ASA Executive Director at the Awards Ceremony.

Dr Prisca Odero, a Centre for Africa Studies (CAS) fellow, received the African Studies Association (ASA) Presidential Fellow award in Indianapolis, USA, recently.

She was nominated for ASA by Dr Cyril Obi from the Social Science Research Council (New York), and was selected competitively, based on her PhD thesis and applied research work in rural development in Africa. Odero obtained her PhD in Africa Studies from the UFS at the July 2014 Graduation Ceremony.

On 22 November 2014, Dr Odero gave a public lecture at the Brooklyn College of the City University of New York. The event was hosted by the Political Science Department at the College.

Her paper, titled Sources and role of social capital in smallholder agricultural production: The value of membership of community groups to Zimbabwe rural livelihoods, sought to address the question of whether social capital contributed to the resilience of rural households in the face of economic difficulties and food security challenges. Dr Odero argued that the link between social capital and agricultural production is manifest in the ways in which farmers use social capital derived from membership of groups to alleviate agricultural production challenges.

Smallholder farmers in Zimbabwe, who face constraints in acquiring the necessary resources for production because of failing markets and reduced agri-industry productive capacity, employ a range of methods to deal with these challenges.  She presented an analysis of data collected through focus group discussions with representative groups and through a household survey.

Dr Odero’s research forms part of a book project. While books on agricultural development knowledge do exist, more studies analysing issues and offering solutions from an African perspective would help to address the gap in African knowledge production.

 

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