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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Nine Kovsie students awarded NAC bursaries

2015-02-19

The UFS is proud to announce that nine of our Drama and Theatre Arts undergraduate students have been awarded National Arts Council (NAC) bursaries for their studies in 2015.

From the left in the photograph, these students are:

• Mbuyiselo Nqodi (first year)
• Marike Jonker (second year)
• Monique de Klerk (second year)
• Aldine van der Merwe (third year)
• Kado Cloete (third year)
• Rondo Mpiti (third year)
• Magnus McPhail (third year)
• Olivia Wyngaard (third year)
• Marica Laing (second year)

This year the amount awarded for the NAC busaries is R70 000.

Since 2005, the NAC has given bursaries to the UFS for the last 10 years. The amount varies from year to year.

“The number of undergraduate students who benefit varies depending on the amount allocated each year,” said Prof Nico Luwes, Head of the Drama and Theatre Arts Department at the UFS.

“Some years, the NAC prescribes how many students will be awarded a bursary and provides a profile of gender and academic prerequisites. Other years, such as the present one, there is no prescription and the UFS was able to cater for the applications submitted, and the number of students who will benefit, within the amount awarded. Normally, it is divided between successful candidates.”

The criteria according to which NAC bursaries are awarded to students every year include academic merit and, of course, their financial situation.”

“The full information of applicants from the Department of Drama and Theatre Arts is checked by the selection committee – all permanent members of staff in the department. The names are then sent to the NAC for approval.
UFS Finances ensures further that the bursary money is paid into the student’s class fees account. During the year and at the end, I report to the NAC on the progress shown by bursary holders. This, in turn, contributes to the excellent co-operation with the NAC so that the following year’s application is then generally successful,” says Luwes.

Bursary monies cover mainly registration and class fees for some or all modules, depending on the amount awarded.

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