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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Tough future if nothing changes in Africa
2015-02-20

 

The Department of Political Studies and Governance at the UFS recently hosted a workshop with the Osaka School for International Public Policy and the Southern African Centre for Collaboration in Peace and Security Studies.

The workshop, which was held on Thursday 12 February, had the theme of Perspectives on African Peace and Security. During workshop sessions, thoughts and views on peace and security were discussed for both African and South African circumstances. This was the fourth year of this joint workshop at the UFS.

Prof Hussein Solomon from the Department of Political Studies and Governance at the UFS shared some notes:

“In terms of South Africa, the fact that only 11% of South Africans have a post-school education holds negative prospects for us attaining a so-called ‘knowledge economy’”, says Prof Solomon.

“This also means that unemployment will continue to remain high since, in certain key areas, the South African economy is quite sophisticated, and needs a sophisticated labour force. Therefore, high unemployment translates into further social unrest, especially if one considers that youth unemployment is approaching 50%.”
 
Moving to broader issues in Africa, Solomon states that governance remains a challenge.

“There is a need to move away from Eurocentric forms of governance to more hybrid forms, implementing a mix of western forms of governance alongside more traditional forms.”

“Otherwise, the probability of conflict remains high as we look into the future. The possibility of water wars between African states is distinct.”

“Terrorism too will be with us for some time to come, with three terrorist attacks per day in Africa. Making matters worse, whether it is conflict over water or terrorist atrocities, is the African Union’s inability to resolve these issues. It simply does not have the capacity”, says Solomon.

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