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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Visiting Professor, Piet Bracke, Speaks on Public Mental Health

2015-02-20

Piet Bracke

Professor in the Department of Sociology at the Ghent University in Belgium, Piet Bracke, recently visited the UFS to speak about his research on the Public mental health and comparative health research: between social theory and psychiatric epidemiology.

At the public lecture on Monday 16 February, Bracke stated that part of the sociological attention to mental health and well-being was rooted in the 19th century's romanticists' discontent with self and society. The classical and contemporary social theorists' views on the disconnection between culture and the ‘real’ self resembles the more recent evolutionary psychological assumptions about the maladaptation of psychobiological mechanisms to contemporary societal arrangements.

In contrast to these perspectives, contemporary psychiatric epidemiological research has a strongly underdeveloped conception about the nexus between society and population mental health. Both perspectives, the social-theory-and-societal-discontent approach and the biomedical psychiatric epidemiological approach, have drawbacks. Starting from the pitfalls of the aforementioned perspectives, they have been exploring the challenges posed by the development of a macro-sociology of population mental health.

Recently, this research domain has received renewed attention of scholars inside as well as outside sociology. The rise of multi-country, multilevel datasets containing health-related information, as well as the growing attention on the fundamental social causes of health and illness, and the focus on population as opposed to individual health, has contributed to the revival of comparative public mental health research. Based on findings from their recent research, they have illustrated how taking the context into account is vital when exploring the social roots of mental health and illness. In addition, they have demonstrated how they can liberate a few so-called ‘control variables’ in risk factor epidemiology – e.g. gender, education, and age – from their suppressed status by linking them to core concepts of sociology. With their research, they hope to further the development of a macro-sociology of public mental health.

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