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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Shimlas now second on Varsity Cup log
2015-02-25

After scoring nine tries to none to establish a 57-0 win over the Central University of Technology’s (CUT) Ixias in round three of the 2015 Varsity Cup Rugby Tournament, the UFS Shimlas are now second on the overall log.

Despite thunder showers in Bloemfontein on the evening of Monday 23 February, the match at the CUT Rugby Stadium continued. Shimlas’ Arthur Williams opened the scoreboard early with the first try of the evening, after getting his hands on a loose ball to break through the CUT defense line. Only four minutes later, Shimlas’ flank Gerhard Olivier scored another try. Both of these tries were successfully converted by Niel Marais, putting Shimlas in a 16-0 lead within less than seven minutes.

By halftime, the Shimlas’ lead had increased to 39-0. Daniel Maartens started the second-half scoring for the UFS when he crossed the try line in the 46th minute to secure Shimlas’ seventh try. After another successful conversion kick by Marais, the scoreboard read 47-0.

The match began to lose its spark as handling errors and ill-discipline became the order of the day. CUT were reduced to 14 men for the second time in the match, when Boetie Makethlo was sent to the sin bin in the 75th minute for an infringement at the breakdown, inches away from his try line.

Maartens went over the try line again in the 78th minute, scoring Shimlas’ eighth try in the match and taking his team’s score beyond the 50 mark. Shimlas managed yet another try in the last minute, with Niell Jordaan diving over the try line for old time’s sake.

Although the Shimlas’ 2015 Varsity Cup started off with a 29-29 draw against the University of Pretoria’s Tuks in Bloemfontein, they returned the following week to clinch a 24-0 win against the University of Johannesburg at the UJ Stadium. Apart from Tuks, who is at this stage on top of the log, no team has scored against Shimlas thus far in the 2015 Varsity Cup.

Up next, Shimlas will face the Stellenbosch University’s Maties side at Shimla Park in Bloemfontein for round four of the tournament on Monday 2 March 2015.

Our Player that Rocks: Niell Jordaan

Shimlas’ point scorers:

Tries: Arthur Williams, Gerhard Olivier (2), Marco Klopper, Vuyani Maqina (2), Daniel Maartens (2), Niell Jordaan
Conversion kicks: Niel Marais 4

 

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