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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

The UFS produces some of the finest teachers in the country

2015-03-02

The quest for producing well-grounded, excellent and prolific teachers at the UFS is bearing fruit. Numerous accolades have over the years been bestowed on some of the UFS Qwaqwa Campus's finest graduates.

"For us as the faculty, it is gratifying and rewarding to learn about the achievements of our students. These achievements do not only validate our efforts, but inspire us as well,” says Dr Dipane Hlalele, Assistant Dean in the Faculty of Education at the UFS.

Dr Hlalele also revealed that, in the recent past, the faculty at the Qwaqwa Campus has experienced an increase in the enrolment figures for teacher training.

"Numbers in our initial teacher education programmes grow in leaps and bounds and we produce some of the best teachers in the country. We are proud to say that on graduation day, our students receive at least two things, i.e., their qualifications as well as entry into the teaching profession," added Hlalele.

Some of the shining examples that Dr Hlalele referred to, are Tebello Tshabalala (English), Mthobisi Khumalo (Mathematics), Thabo Mohapi (Physical Sciences), Lehlohonolo Khanye (Accounting) and Yvonne Tsotetsi (Business Studies). All of these are educators at Lekgulo Senior Secondary School in Qwaqwa and have each produced a 100% pass rate in the 2014 examinations.

There is also Nape Motloung, whose excellent Mathematics results at Botshabelo's Lefikeng High School have placed him as the Top Mathematics Educator in the Free State. Motloung's consistent excellent results have also placed his school in the Top 10 of the Best Performing Schools in Mathematics. This has also won his school R100 000 from the Free State Department of Education.

At yet another Qwaqwa school, Sekgutlong Secondary, Malefetsane Mokomotoane's Mathematics results over the years have earned him a runner-up prize in the category Excellence in Teaching Mathematics at the 2014 National Teachers Awards hosted by Minister Angie Motshekga.

"I am proud to have had 98% of my learners pass Mathematics, with 10 distinctions," said an elated Mokomotoane, who has just been appointed Principal of Selelekela Secondary School in Qwaqwa.

"Having achieved an average of 59%, my highest ever, has taught me and my learners that through hard work, anything is possible," added Mokomotoane.

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