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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

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Co-architect of peace and reconciliation in Northern Ireland to present Annual Reconciliation Lecture today
2015-03-03

Colm McGivern, Director of the British Council in South Africa

To emphasise the University of the Free State’s Human Project, the UFS has positioned itself as an institution that is recognised across the world not only for excellence in academic achievement, but also in human reconciliation. The Annual Reconciliation Lecture, whose organising committee is chaired by Prof Pumla Gobodo-Madikizela, is a unique and major initiative to enhance this important vision of our university.

This year, Colm McGivern, Director of the British Council in South Africa, will present the Fourth Annual Reconciliation Lecture at the Centenary Hall on Thursday 5 March 2015.

Colm McGivern was brought up in Northern Ireland at the height of the conflict that has come to be known as the ‘Troubles.’ His early experiences of conflict, sectarianism, and living in a divided society have driven his career, and his personal commitment to peace-building and promoting reconciliation.  He was a student leader at Queen’s University in Belfast during the time of the first IRA Ceasefires in the 1990s, and then worked in the Higher and Further Education sectors, and at a community level with peace-building groups across Northern Ireland and internationally. He was Director of the British Council in Northern Ireland for four years and, in that role, facilitated discussions between divided communities before and during the Ceasefires and Peace Process, with a particular focus on bringing young people together across Ireland.

In his role as Director of the British Council, McGivern has created thousands of cultural and educational connections between the UK and SA. Every year, he ensures that young South Africans can get access to educational and cultural opportunities that are life-changing while deepening their connection with the UK.

A highlight of this year’s lecture will be a performance by musicians from the Odeion School of Music, Tumi Ntantiso (soprano), Bertha Menyatso (mezzo-soprano), Malefetsane Mofokeng (baritone), and Cezarre Strydom (piano). They will be performing works from ‘Tales of Hoffmann’ by Jacques Offenbach, among others.

Members of the public and media are welcome.

RSVP: Jo-Anne Naidoo, e-mail: Naidooja@ufs.ac.za

Date: Thursday 5 March 2015
Time: 17:30 (please be seated by 17:15)
Venue: Centenary Complex, Bloemfontein Campus

 

The event will be streamed live on: http://livestream.ufs.ac.za/

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