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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

OSM piano lecturer on jury for Unisa National Competition
2015-03-05

Prof Ruth Goveia
Photo: Supplied

Prof Ruth Goveia, a piano lecturer at our university’s Odeion School of Music (OSM), was chosen to serve on the jury of the 5th Unisa National Piano Competition. This will take place from 11 to 18 July 2015 at the ZK Matthews Hall on the Unisa Muckleneuk Campus in Pretoria.

Prof Goveia holds a doctorate in Music in Piano from the prestigious Jacobs School of Music at Indiana University in the USA, and has a master’s degree in Piano Performance from the College-Conservatory of Music at the University of Cincinnati, also in the USA. Prof Goveia is an experienced adjudicator, and is regularly engaged for both national and international piano competitions, festivals, and examinations.

She is a dedicated teacher, who enjoys working with both students and professional musicians. Several of her students have excelled in competitions and examinations, and enjoy successful careers.

The Unisa National Music Competition was founded with the main objective of providing young South African pianists with the necessary experience, requirements, and procedures of an international piano competition. The winner of the national competition has automatic access as a participant in the next scheduled Unisa International Piano competition. The prescribed repertoire requirements of the national competition always correspond closely to those of the next Unisa International Piano Competition.

Competitors will be subject to the same adjudication criteria and processes applicable to international piano competitions. The Unisa Music Foundation’s next piano competition will have a jazz category running parallel to the classical category.

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