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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Prof Mary Kay Blakely from the Missouri School of Journalism (USA) speaks about the age of misinformation
2015-03-10

 

Prof Mary Kay Blakely  

Living in an age where misinformation is as common as loadshedding in South Africa, we all tend to ask who we can trust when reading or hearing the news media.

Prof Mary Kay Blakely from the Missouri School of Journalism (Columbia, USA) presented a public lecture recently entitled The age of misinformation: Who do you trust? at the UFS. She stressed the point of how, with the social media revolution and the rise of the citizen journalist, our news interests of old are being fed by many more new channels, influences, and opinions. This leaves us to question what is still true and what is still objective

For example, Blakely mentioned that “gossip, scandal, and celebrities have always been our fascination – even more so today.”

“But nowadays, we have to become even more critical thinkers.”

During Blakely’s presentation, she stated the harsh reality that objectivity is extremely difficult. True objectivity, which means keeping  yourself completely out of the story you cover, is virtually impossible.

“It is not just about covering both sides of the story. Often, there are far more sides to a story than just two, probably even five.”

Therefore, it comes down to fairness, balance, and truth, which are really important in covering a story. Hence, it is the obligation of the media to be fair, balanced, and truthful while recognising their own biases. 

Prof Mary Kay Blakely – Short Bio:

Prof Mary Kay Blakely is the author of the critically-acclaimed books Wake Me When It's Over, American Mom and Red, White and O So Blue. Her essays on social and political issues have appeared in The New York Times, The Washington Post, Mother Jones, LIFE, and Vogue, among others.

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