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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Bring back dignity to our schoolgirls
2015-03-10

A Kovsie student initiative is currently crying out to the community at large to help in realising a dream of helping school learners who come from poor families to gain confidence in their school work and social lives generally. 

 

This initiative by Nkanyezi Talk @UFS aims to do this through the provision of sanitary towels to such learners at the onset of puberty.

 

“Through research, we have established that some learners face numerous challenges during this stage, with some using socks as a substitute for sanitary towels while others opt for newspapers. This raises a lot of health and psychological concerns,” says project coordinator Bongani Zwane.

 

According to research conducted by UNICEF in 2013, one in ten girls who cannot afford sanitary towels will miss a week of schooling during the cycle of their period. This is because they fear being ridiculed by other learners, and because their dignity as girls is not being respected. This absence from school also happens because they do not understand what is happening to their bodies.

 

“What should be a celebration of womanhood becomes a time of shame and embarrassment with dire consequences for the girls’ education as well as their future,” Zwane adds.

 

“We therefore appeal to everyone to help us realise this dream of making sure that we reduce the number of schoolgirls who do not attend school during their menstruation periods, and restore their dignity by donating sanitary towels.

 

“Overall, we have already collected more than 1000 packs of sanitary towels. The office of Cornelia Faasen, our acting dean of Student Affairs, has also endorsed the campaign and already donated 600 packs of sanitary towels,” says Zwane.

 

“We have set ourselves the goal of collecting and donating 10 000 (ten thousand) sanitary towels in total.”

 

 

Methods of Donating

 

Nkanyezi Talk @UFS welcomes any physical donations of sanitary towels and financial donations through their UFS entity number 1/466/08119 only.

 

For more information on how and where to donate, please contact project coordinator Bongani Zwane at 079 237 5089 or email him to bzwane@workmail.co.za.

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