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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Kovsies raise their voices to say no to racism – and yes to equality

2015-03-13

SRC President, Mosa Leteane
Photo: Hannes Pieterse

Launch of the No-to-Racism/Yes-to-Equality Campaign : Video

In support of National Human Rights Month, the UFS has launched the No-to-Racism/Yes-to-Equality Campaign. Through this campaign, the entire UFS community reaffirms its commitment to equality, respect, democracy, social justice, humanity, dignity, human rights, and diversity.

The first leg of the campaign, No-to-Racism, was launched at the Qwaqwa, Bloemfontein and South Campuses during the past month. “Look in the mirror tonight and have a discussion with yourself,” Prof Jonathan Jansen, Vice Chancellor and Rector of the UFS, said during the launch at the Bloemfontein Campus. “Ask yourself to what extent can I truly say, ‘I am dealing with my racism, my bigotry, my ethnicism, my homophobia, my xenophobia? Am I truly dealing with those in my life?’”

Through the No-to-Racism Campaign, staff and students are encouraged to take a public stand against not only racism, but also homophobia, sexism, ableism, xenophobia, classism, ethnicism, ageism, and all forms of intolerance and othering.

The start of No-to-Racism will closely be followed by the Yes-to-Equality Campaign, which will be launched on 1 April 2015.

SRC President, Mosa Leteane, urged the Kovsie community to make South Africa work. “We say ‘no’ because we want to say ‘yes’. Fix your ‘no’ so that your ‘yes’ is clear, it’s equal, it’s honest. That is what ‘yes’ looks like.”

The campaign is also aligned with the declaration made by the UFS Council in November 2014 in which it was stated that “the Council of the University of the Free State believes very strongly in the human dignity, equality, and freedom of all people. Accordingly, the Council reaffirms its abhorrence of acts of racism, sexism, and unfair discrimination of any kind or in any form”.
The No-to Racism/Yes-to-Equality Campaign is an initiative of the Institute for Reconciliation and Social Justice, together with the SRC.

Important dates:
1 April 2015: Launch of Yes-to-Equality Campaign on the Qwaqwa and Bloemfontein Campuses
13 April 2015: Pledge of the UFS community at 12:45 on the Red Square, Bloemfontein Campus

For more information or enquiries contact news@ufs.ac.za.

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