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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Prof Marais awarded the first UFS Book Prize for Distinguished Scholarship
2015-03-19

Prof Kobus Marais

Prof Kobus Marais, from the Department of Linguistics and Language Practice, was recently awarded the UFS Book Prize for Distinguished Scholarship for 2014.

The prize, awarded for its first time in 2014, consists of an inscribed certificate of honour with a monetary award of R50 000 paid into Marais’s research entity. The book for which Marais received this award is Translation Theory and Development Studies: A Complex Theory Approach (2014, Routledge, New York).

“It falls within the discipline of translation studies, but it is actually an interdisciplinary approach, linking translation studies and development studies,” says Marais.

Therefore, it aims to provide a philosophical underpinning to translation, and relate translation to development.

“The second aim flows from the first section’s argument that societies emerge out of, amongst others, complex translational interactions amongst individuals,” Marais says. “It will do so by conceptualising translation from a complexity and emergence point of view, and by relating this view on emergent semiotics to some of the most recent social research.”

It fulfils its aim further by providing empirical data from the South African context concerning the relationship between translation and development. The book intends to be interdisciplinary in nature, and to foster interdisciplinary research and dialogue by relating the newest trends in translation theory, i.e. agency theory in the sociology of translation, to development theory within sociology. 

“Data are drawn from fields that have received very little if any attention in translation studies, i.e. local economic development, the knowledge economy, and the informal economy, says Marais.”

The UFS Book Prize for Distinguished Scholarship was initiated in 2014 to bestow recognition on any permanent staff member of the UFS for outstanding publications which consist of research published as an original book, on the condition that the greater part (50% or more) of the book has not been published previously. This stimulates the production of significant and original contributions of international quality by our staff. In this way, the UFS is striving, through a series of award-winning books, to enhance the quality of specialised works published by our staff members.

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