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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Juan Odendaal on his way to World Champs
2015-03-23

Juan Odendaal
Photo: BOOGS Photography, Andrew McFadden

UFS’s athletes with disabilities are currently excelling in cycling and athletics.

The UFS Para-cyclist, Juan Odendaal, will soon make his debut for South Africa at the 2015 Union Cyclist International (UCI) Para-cycling Track World Championships in Apeldoorn, The Netherlands, from 26-29 March 2015.

The Championship event will provide an excellent foundation for re-building the international competitiveness of South Africa’s Para-cycling track team in the build-up to Rio 2016. In a situation where the UCI has hosted relatively few international track competitions over the past three years, the 2015 World Championships will serve as a stepping-stone to the 2016 grand season, when it is expected that the country’s top riders will reach their peak competitive condition.

As the youngest member of the South African team, Odendaal will use the opportunity of competing in the individual time trial and team sprint events to build a platform for an international career will certainly span many years to come.

Another UFS student, Musa Simelane, are excelling and was chosen for the SA Wheelchair Rugby tean, known as the "Wheelboks". They will compete in the 2015 World Wheelchair Rugby Challenge in London in October and after that head to Japan to compete in the 2015 Asia Oceania Championships.

On a local level, earlier in March this year, other UFS athletes with disabilities also performed well on the athletics track.

Blind athlete and member of the Bloemfontein Campus Student Representative Council (SRC), Louzanne Coetzee, also had a good 1500m race in the beginning of March when she qualified easily for the World Championships, which will take place in Toronto, Canada, later this year. Coetzee and her guide, Rouxné Jacobs, set up a time of 5:45.86, which is well under the required standard of 6 minutes.

The other blind UFS athlete, Danie Breitenbach, alongside his guide Marius Wessels, broke his own national record for the 800m again on Friday 6 March 2015. In November 2014, Breitenbach’s record stood at 2:15.17. This record now stands at 2:13.57. Chances now are that Breitenbach will reach his goal of running the 800m under 2:10 at the Nedbank National Championship for the Physically Disabled at the end of March 2015.

The other Kovsie stars who will be participating at the Nedbank National Championship for the Physically Disabled are as follows:

Athletes:
• Dineo Mokhosoa
• Louzanne Coetzee
• Danie Breitenbach
• Juanré Jenkinson
• Diederich Kleynhans
• Jacques de Bruyn

Swimmer:
• Johann van Heerden

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