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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

UCT scholar in Philosophical Psychology of Black Existence to join Judge Albie Sachs on stage
2015-03-23

Dr Buhle Zuma, listed as one of the 2011 Mail & Guardian 200 Young South Africans, is coming to the Bloemfontein Campus. He will share a stage with civil rights activist and former Constitutional Court, Judge Albie Sachs, on Thursday 26 March 2015 in the Albert Wessels Auditorium at 12:30.

Respondent to Judge Sachs

A former Mandela Rhodes scholar, and currently a young lecturer at the University of Cape Town's Psychology Department, Dr Zuma is particularly interested in issues at the heart of our rainbow nation . His research asks the question: What does it mean to be human for black people after centuries of dehumanisation? Dr Zuma also looks at the role of desire and fantasy in the political imagination of post-apartheid South Africa. He describes his developing thought and work as the Philosophical Psychology of Black Existence.

Dr Zuma will act as respondent to Judge Sachs’ public lecture, ‘Sites of memory, sites of conscience’ [Hannes, please link to the article on the main website]. This lecture will form part of a series that focuses on how the creative arts represent trauma and memory – and how these representations may ultimately pave the way to healing historical wounds.

Vice-Chancellor’s Lecture Series on Trauma, Memory, and Representations of the Past

This lecture will launch of the Vice-Chancellor’s Lecture Series on Trauma, Memory, and Representations of the Past. It forms part of a five-year research project led by Prof Pumla Gobodo-Madikizela [], funded by the Mellon Foundation []. The event is hosted by the UFS Trauma, Forgiveness and Reconciliation Studies [].

Dr Zuma lives by the belief that, if he imparts what he learns and knows lovingly and creatively, the world will be the better for it.

Details of the event:

Date: Thursday 26 March 2015
Time: 12:30
Venue: Albert Wessels Auditorium, Bloemfontein Campus
RSVP: Jo-Anne Naidoo at Naidooja@ufs.ac.za

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