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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Student rights revived
2015-03-30

Lindokuhle Ntuli fulfils his promises.

“I can assure you that each and every promise that I’ve made to the students will be fulfilled.”

That is a promise that Lindokuhle Ntuli, SRC Legal and Constitutional Affairs (Bloemfontein Campus) gave to Kovsie students. The fourth-year LLB student and founder of the UFS Legal Behemoth describes himself as an ambitious person with a passion for law, order, and formality.

He explains the duties of his portfolio as “the office that will really ensure that the interests of all students are catered for. That student’s consumer rights are respected and not violated.” Through his portfolio, he aims to make sure that students are aware of what their rights are.

As part of his portfolio, Ntuli has re-introduced the Student Court, which will be fully functional during the second semester. The portfolio also introduced the Student Engagement Forum.  The purpose of the forum is for students to share their grievances with regards to student rights violations. These discussions will take place twice a semester.

“The student engagement forum is the means by which we are able to really assess what kind of rights of the students are being violated,” Ntuli added.

Together with Louzanne Coetzee, SRC Accessibility and Student Support, Ntuli aims to establish the Student Rights Desk. The desk will deal directly with student rights on campus without recourse to the student court or external courts.

When asked about what his vision for the SRC is, Ntuli responded:

“My vision for the SRC is to see the SRC really attending to each and every need of students. We must advocate for students in the best way we can.”

And the words Lindokuhle lives by?

“Law and order exist for the purpose of establishing justice, and when they fail in this purpose, they become the dangerously structured dams that block the flow of progress” (Martin Luther King Jnr).

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