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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Shimlas: Unbeaten Varsity Cup Champions!
2015-04-14

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    Photo: Johan Roux
    Spotlight Photo: Spektor Photography
    Photo gallery

The UFS Shimlas rugby team made history on Monday 13 April 2015 when they won their first ever Varsity Cup tournament, beating North-West University (NWU) Pukke 63-33 in the final.

Not only did Shimlas make history by winning their first-ever tournament title since the inaugural tournament in 2008, but they did not lose a single game in the 2015 Varsity Cup, thus claiming the cup in front of their home crowd at Shimla Park in Bloemfontein.

Shimlas outscored their traditional intervarsity rivals with nine tries to four. Pukke put the first points on the scoreboard with a penalty kick. The home side started off slowly in the first half. However, Shimlas’ lock, Johan van der Hoogt, did score the first try of the match followed by flyhalf and player that rocks, Niel Marais’s successful conversion kick. Yet, the men from the North-West retaliated full force for the greater part of the first half and, two tries later, had a 18-8 lead over the UFS team. 

Shortly after the first strategy break, Shimlas No.8, Niell Jordaan, crossed the try line following a driving maul, but the visitors received another penalty and succeeded with the kick at goal. The last ten minutes before half time saw Shimlas taking advantage, with the Pukke skipper being sent to the sin bin. Wing Maphutha Dolo hit a gap in NWU’s defense, and scored the try that put Shimlas in the lead again. Not long after, Marais sparked in making a play, offloading to flank Daniel Maartens to score a final try before half time, securing a 26-20 lead.

The second half had not been in play too long when the home side crossed the try line again, scoring their fifth try. Marais was again central in creating the play that saw Shimlas outside centre, Nico Lee, putting the points on the board.

NWU fought back again, scoring a pushover try from a scrum. But Shimlas would not give up the lead again, and a well-timed pass from Marais had Lee crossing the line for his second try.

More Shimlas tries piled up from Marais, Dolo, and Maartens, leaving the Potchefstroom side behind 63-25, giving them little opportunity to score again. One desperate consolation try by Pukke in the final seconds did manage to close the gap on the scoreboard, but it was not nearly enough to snatch the title from the hungry and undefeated Shimlas.

FNB Player that Rocks: Niel Marais
Shimlas point scorers:
Tries: Johan van der Hoogt, Niell Jordaan, Maphutha Dolo (2), Daniel Maartens (2), Nico Lee (2), Niel Marais
Conversions: Niel Marais (6)

 

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