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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Kovsie community pledge to advance equality and eradicate racism
2015-04-15

Photo: Johan Roux

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Speech by JC van der Merwe

On Monday 13 April 2015, the University of the Free State drew a line in history. Staff and students united in a singular vision: equality.

Since March 2015, the Institute for Reconciliation and Social Justice, together with the SRC, has launched the No-to-Racism/Yes-to-Equality Campaign across all three campuses with tremendous success. This campaign has now reached a high point at which the Kovsie community pledge their commitment to entrenching a culture of equality at the university. The first pledge ceremony took place on 13 April 2015 at the Bloemfontein Campus. Kovsies thronged to place their inked thumbprints on pledge posters in an inspirational show of solidarity.

“The key to transformation,” Prof Jonathan Jansen, Vice-Chancellor and Rector of the UFS, said, “is putting yourself in the shoes of the other person.” When you look past yourself and acknowledge others’ experiences, the world starts to look different. A pledge, Prof Jansen continued, is a solemn promise – not only to stop bad behaviour, but to go forward resolutely with good behaviour. “You do not change a campus, you do not change a country, without being courageous,” Prof Jansen said.

The message from Mosa Leteane, President of the Student Representative Council (SRC), echoed the same belief. “Today,” Leteane said, “the UFS takes a bold and courageous step toward equality.” This new generation, which includes young people from all races, has started a new revolution. A generation that says no to discrimination and yes to equality. “We cannot afford to be ignorant or indifferent,” Leteane urged.

The remaining two campuses will also have an opportunity to publically pledge their support on the following days:
Qwaqwa Campus: Wednesday 15 April 2015
South Campus: Friday 17 April 2015

To enable the university to go beyond dialogues and consultation towards active decision-making, a University Assembly will be held on Tuesday 28 April 2015. The assembly will serve as a space for critical engagement among all university stakeholders to focus on issues such as symbols, policies, practices, and curriculum. Staff and students are encouraged to submit matters for discussion to JC van der Merwe (vdmjc@ufs.ac.za) before 22 April 2015.

The No-to-Racism/Yes-to-Equality Campaign is aligned with the declaration made by the UFS Council in November 2014, in which it states that “the Council of the University of the Free State believes very strongly in the human dignity, equality, and freedom of all people.”

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