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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

One from UFS elected as Vice-President of ASAQS
2015-04-20

Stephen Ramabodu and Dr Marléne Campbell, Stephen’s promotor during his studies.
Photo: Leonie Bolleurs

The university is very proud of the election of Dr Stephan Ramabodu, from the Department of Quantity Surveying and Construction Management, as Vice-President and the chairman of the fees committee of the Association of South African Quantity Surveyors (ASAQS).

ASAQS aims to advance and promote the science and practice of quantity surveying, uphold the dignity of the quantity surveying profession, and promote the high standards of professional competence and integrity, among other things. Members of the ASAQS receive guidance and resources to succeed in quantity surveying, and to stay abreast of developments in the built environment today and in the future.

The ASAQS also provides an environment in which professionals may learn, grow, and work together to advance the techniques and science of quantity surveying. The ASAQS include quantity surveying professionals from every area of the construction industry, from private practice, government and quasi-government organisations to construction companies.

Stephan completed his quantity surveying (QS) degree as well as a master’s degree in Land and Property Management at the University of the Free State. In 2014, he completed his PhD, making him the first black South African PhD holder in the Department and one of the few QS PhD holders nationwide. 

In 2002, Stephen was appointed as a lecturer in the Department of Quantity Surveying and Construction Management under a programme called Grow Your Own Timber. He went to gain some commercial experience in Cape Town, where he worked for Davis Langdon. In 2008, he came back to the Free State, where he established Ramabodu & Associates Later that year, he returned to the university as a lecturer to complete all the remaining milestones of the Grow Your Own Timber programme.

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