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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

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UFS Autumn Graduation inspires perseverance
2015-04-20

 

Louzanne Coetzee and her guide dog, Oakley after she received her degree at the UFS’s Autumn Graduation.
Photo: Gerhardus Bosch

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Autumn has seen the UFS’s first graduation ceremonies of the year on the Bloemfontein Campus. From 14 to 17 April 2015, a total of 3 660 graduates were rewarded for their hard work while top speakers addressed them in the Callie Human Centre.

UFS Chancellor, Dr Khotso Mokhele, commented the more than 250 students who passed their degrees with distinctions at the autumn graduation.

Prof Soodyall, a Medical Scientist at the South African Institute for Medical Research as well as  Principal Medical Scientist for the National Health Laboratory Service, and Director for the Human Genome Diversity and Disease Research Unit at the University of Witwatersrand delivered the first motivational message of the April Graduation. The group of graduates in the Faculty of Natural and Agricultural Sciences listened as she shared her story with them.
 
"My own career – with no grand design or script – steered me into conducting genetic research on human populations from sub-Saharan Africa with a focus on a better understanding of human evolution, and to reconstruct the prehistory of African populations. While giving graduates a glimpse on how her career progressed, Prof Soodyall said: "I share these stories with you to give you some reassurance that you do not need feel that you have to figure out every minute detail of where to from here. Things fall into place with hard work, dedication, and dreams.

The developed world is forging ahead with interventions, so the gap between the developed world and the developing world continues to grow bigger. Prof Soodyall said: “You have the unenviable opportunity to think strategically, and to use the modern tools in your respective fields to make significant advances to transform our society, and to contribute to making it a better place for all. We need to embrace the current challenges, and build networks and bridges across disciplines to close the gaps, to work beyond the cultural barriers, and to ensure equity in access to health, water, education, etc, for all, as we would wish these things for ourselves and our families.

Read the full story of the Autumn Graduation 2015

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