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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

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KovsieSport celebrates three varsity tournaments' titles
2015-04-21

Both staff and students celebrated the Shimlas, KovsieTennis, and KovsieNetball’s achievements.
Photos: Hannes Pieterse

 

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In this week of graduation ceremonies, the University of the Free State had more than its academic achievements to celebrate. The Shimlas’ brilliant triumph in the Varsity Cup as well as the achievements by KovsieTennis and Kovsie Netball was celebrated at a colourful event on the Bloemfontein Campus.

At the celebrations, which were well supported by the campus community, the Vice-Chancellor and Rector, Prof Jonathan Jansen, congratulated all three teams on their outstanding achievements. Not only did the Shimlas walk off with the Varsity Cup, they also won every game they played. AJ Coertzen, the Shimlas’ captain, said: “Although we were well prepared and physically fit, the fact that we played for one another contributed much to our success. As a team, we have grown from friends to brothers.”

KovsieTennis was congratulated on wearing the USSA tennis crown for the fourth consecutive year. In addition, they have the following triumphs to their name: 2007 – SASSU (South African Students Sports Union) (Ladies); 2008 – USSA (University Sport South Africa) (Ladies) and 2009 USSA (Men). Duke Munroe, captain of the KovsieTennis team took the opportunity to thank the team personnel. He believes that hard work behind the scenes by the coach, Marnus Kleinhans, and the team manager, Janine de Kock, contributed greatly to the team’s success.

KovsieNetball was also praised for their successes. In 2014, under the captaincy of Karla Mostert, they won gold at the Varsity Netball championships. They also won the National Premier League. The UFS is also proud of its netball players in various national teams: SA Under 19-23, the Protea groups, and the SA University team.

At the celebrations, Karla said: “The environment and the people you surround yourself with dictate how easily you achieve success. Our achievements and successes are evidence of the quality of the coaches, supporters, and facilities available to us.

After the event on the Red Square, the teams made an appearance in the Callie Human Centre, where they were enthusiastically congratulated by graduands, their families and the university management. Dr Khotso Mokhele, Chancellor of the UFS, also praised the teams for their achievements. “You are a team without individual stars. That is the sort of team I want to be part of.”

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