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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

UFS Department of Computer Science and Informatics motivates programming success among learners

2015-04-23

From Sentraal High School are from the left: Albert Dreyer (full marks, Grade 9); Corlé van der Walt (full marks, Grade 10); Janco Venter (full marks, Grade 10); Soné du Pisanie (full marks, Grade 10) en Handré Venter (Grade 9).

A group of learners from the Free State, who are taught at and by the University of the Free State’s Department of Computer Science and Informatics (under the Python project), came first in the Talent Search round of the South African Computer Olympiad (SACO).

According to Dr Anelize van Biljon, senior lecturer in the Department of Computer Science and Informatics, the Olympiad is presented in three main rounds: the Talent Search, the Application Olympiad, and the Programming Olympiad.

At the UFS’s Department of Computer Science and Informatics’ Python project, pupils from various schools in Bloemfontein attend programming classes where they are taught by staff and students of the department. These students are benefitted by the opportunity to transfer their knowledge to others. All the classes are free of charge.

Anelize explains: “The name was chosen because we use the Python programming language. It is a language with considerable appeal – not one of the fastest – which can be learnt relatively quickly, and which conforms to SACO requirements. The purpose of this programming is to implement algorithms (the learner is given a problem, makes a plan to solve it, and does the necessary programming). Thus, it is not about the looks of the programme, but about its effectiveness and speed.”
Anelize is the initialiser and co-ordinator of the Python project. "I started this project in 2010 in the Department of Computer Science and Informatics for learners from Grades 6 to 12 to encourage them to take the subject. These classes exposed them to something more than school work. I enjoy this kind of competitions and am also very involved with Maths Olympiads.

Achievements such as these are good advertisements for the Department of Computer Science and Informatics,” she said.

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