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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Thinking stone artist on his way to Italy
2015-04-29

Willem Boshoff

Professor extraordinary at the UFS Department of Fine Art, Willem Boshoff, together with other South African artists, will represent the country next month at the Venice Biennale.

The 56th Biennale takes place between 9 May and 22 November 2015. It is regarded as the world’s most important art event, with 53 countries taking part. This year the artists will take part in the exhibition entitled What remains is Tomorrow, which will take place in the Arsenal complex in the Italian city of Venice, where it will be on view.

Boshoff was responsible for one of the sculptures known as the Thinking Stone, that may be seen in the middle of the Bloemfontein Campus, in front of the Main Building and next to Red Square.

This work consists of a 32-ton black granite block excavated from the Boschpoort stone quarry in Belfast, Mpumalanga. The block has engravings that are copies of the prehistoric rock paintings (also known as petroglyphs) from Driekopseiland (a prehistoric rock art area near Kimberley). Together with the engravings, on the front of the block, there are sand-blasted inscriptions in six languages of verses and well-known quotations that refer to the word “rock”. These inspire further thought and contemplation. Boshoff has created similar works, including Children of the stars, situated at the Cradle of Mankind.

Boshoff is also known for very innovative and conceptual works, and has created various public artworks, both nationally and internationally. His work includes commissions from the University of Johannesburg, The Constitutional Court, the Mpumalanga Legislature in Nelspruit, and South Africa House in London’s Trafalgar Square.

His work focuses regularly on relationships and social interaction. Generally, they are also the subject of subsequent discussions.       

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