Latest News Archive

Please select Category, Year, and then Month to display items
Previous Archive
12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Kovsie TV Launched
2015-05-06

Victor Ngubeni, Grace Thoabala, Nangamso Dlatu, Aisha Poswa, Lesego Maakamedi, Nothando Hlope, Aldene vd Merwe and Lawrence Siyoko

“We have to change our university before we can change our country.”

 

There is a revolution at hand, and students are requesting new and exciting platforms on which they can voice themselves. Kovsie TV aims to do just that for Kovsie students. 

 

As a student initiative, the steam behind it is SRC Student Development and Environmental Affairs, Victor Ngubeni. He says that it is only right that it be by the students themselves. The launch saw many from the campus community gathered out of curiosity and excitement for the new venture. The evening started out as quite a classy frenzy, which had attendees clearly prepared for the level of broadcasting that the launch would showcase.

 

The initial idea is to increase the number of platforms where students can receive information. The Student Media portfolio, which oversees the functioning of student media platforms, aims to make Kovsie TV as autonomous as possible. As an introductory initiative, it will aid in the sharing and telling of students’ stories.

 

It is important to mention the preparation process that was endured by the many hopefuls who auditioned, hoping to make it as one of the Kovsie TV presenters. For more than three weeks, the panel of judges sieved through the contestants until they had just six rough diamonds. Then, for the first time, the audience met the faces that they would become familiar with from this point.

 

As Ngubeni stressed during his speech, Kovsie TV would not serve as propaganda machine for the SRC, as many might have asked about the relationship that could be expected between the two. The architects of Kovsie TV hope that, as a student initiative, it will inspire a new era in student activism.

 

When asked about the concept behind this new platform, Ngubeni informed us that, “the concept is to have a twenty-minute campus TV show highlighting what goes on around campus so that students know, and so that we can get them participating in campus life activities.”

 

This is a student initiative whose future will depend solely on the students themselves.

 

Presenters:

Nangamso Dlathu – Studio presenter

Grace Thoabala – Studio presenter

Lesego Maakamedi – Social events

Nothando Hlophe – Current affairs

Aldine van der Merwe – Culture events and Vox-Pop

Mbulelo Siyoko – Culture and Vox-Pop

Aisha Phoswa ? Sports

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept