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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

UFS mourns the death of valued Member of Council
2015-05-15

Father Patrick Towe

The senior leadership of the University of the Free State (UFS) is deeply saddened by the passing away of Father Patrick Towe on Wednesday 6 May 2015, following a period of illness. Father Towe served as Chairperson of the university’s Campus Ministries Forum (CMF) for several years, and had been its representative on the UFS Council since 2006.

“Father Towe was an extremely valuable member of the UFS Council. His insight into and knowledge of university business always contributed greatly to the spirit in which the deliberations of Council took place. He will be dearly missed. Our deepest condolences go to his family, friends, the students of ACTS, as well as the congregation in Heidedal, which he served,” said Judge Ian van der Merwe, Chairperson of the UFS Council.

“I remember Father Towe fondly for his pastoral availability to staff and students during moments of crisis from the time of the Reitz incident to those times in which we lost precious student lives. He would call us to prayer and consolation, and for these gifts from Father Towe I am deeply, deeply grateful,” said Prof Jonathan Jansen, Vice-Chancellor and Rector of the UFS.

Father Towe, OMI (Missionary Oblates of Mary Immaculate) represented the Association of Catholic Tertiary Students (ACTS) on the Campus Ministries Forum. As Student Chaplain, he served the university student body through the Catholic Christian Ministry, providing spiritual guidance and support. He took up campus ministry in Bloemfontein in November 2002, and developed a quasi-parish within the student communities on campus.

He received his education in the United Kingdom where he was ordained in 1975. Throughout his career, Father Towe had a special involvement with community development and youth work. He worked as the Roman Catholic Chaplain at the University of Southampton from 1996 to 1998, providing pastoral care to both students and staff of the university. He served as Parish Priest of Christ the King in Heidedal, Bloemfontein.

“Father Towe was instrumental in reviving the CMF, and getting many more churches on campus involved. He had a heart for seeing churches with different backgrounds and focuses unite in making a difference at the university. He was a true gentleman, and was willing to listen to and negotiate with people, without compromising his values. He also did great work among the people of Heidedal towards the end of his life, and we will miss his presence on the CMF”, said Pastor Alistair Kingwill, current Chairperson of the CMF.

 

Media Release
Lacea Loader
Director: Communication and Brand Management
Tel: +27(0)51 401 2584
E-mail: news@ufs.ac.za

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