Latest News Archive

Please select Category, Year, and then Month to display items

PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

UFS History lecturer becomes Visiting Fellow at Harvard

2015-05-25

Dr Chitja Twala
Photo: Eugene Seegers

Prestige Scholar and lecturer of African/South African History at the UFS, Dr Chitja Twala, was recently accepted as a Visiting Fellow at the Harvard Graduate School of Arts and Sciences (GSAS).

A Visiting Fellow status is available to individuals holding a doctoral degree to pursue independent research at Harvard. The Fellowship is for non-degree purposes but aims at the enhancement and further intellectual development of those involved. It focuses on enrichment and development programmes.

Twala was appointed in the Department of History at the UFS in the beginning of 2003. His research field is Liberation History, with specific reference to the liberation movements on the SADC region. He has published extensively on this field and presented papers in local and international conferences.

“I applied (to Harvard GSAS) in April 2014 for the Fellowship through the South Africa Harvard Fellowship Programme,” says Twala.

“After being successful in the interviews conducted by the GSAS panel in July 2014, I had to apply for admission in the Department of African and African American Studies at Harvard, and got accepted for the Fall Semester of 2015.”

At Harvard, Twala will be mentored by Prof Emmanuel Akyeampong (African History Expert).

“Firstly, my main assignment will be to grasp a much deeper theoretical knowledge/framework in historical studies and a broader repertoire of methodologies in the field of African History. Secondly, if time permits, I will be presenting seminars and attending some in a very challenging, stimulating, and intellectually demanding environment where my ideas can be tested and expanded. Thirdly, I will be exposed to new trends as far as African historiography is concerned. Lastly, I will informally engage and exchange some ideas with some experts in the field of African History.”

The programme was recommended to Twala by the Vice-Chancellor and Rector, Prof Jonathan Jansen and Prof Ian Phimister, Centre for Africa Studies Senior Professor at UFS.

“As per the priorities of the Prestige Scholarship Programme, the Fellowship will assist in inculcating in me the intellectual breadth and depth required to pose critical questions and generate ground-breaking knowledge for History as a discipline. It is important for the UFS to establish and sustain international networks with other leading universities and scholars around the world.

“I applied for this Fellowship in order to advance further and broaden the scope in the three areas of scholarship in higher education: discovery, teaching, and public engagement,” says Twala.

Twala will be leaving for Harvard by mid-August and will return by the end of December 2015.

Back

Economic and Management Sciences

Education

Health Sciences

The Humanities

Law

Natural and Agricultural Sciences

Theology and Religion

Open Distance Learning

Business School

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept