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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Alcinda Honwana: Youth Protests Main Mechanism against Regime
2015-05-25

Prof Alcinda Honwana

"Enough is Enough!": Youth Protests and Political Change in Africa (speech) 

The Centre for Africa Studies at the UFS hosted an interdisciplinary project on the Bloemfontein Campus from 20-22 May 2015.

The project, entitled Contemporary Modes of Othering: Its Perpetuation and Resistance, looked at different perspectives, representations, and art forms of otherness, how it is perceived, and how it is resisted.

The annual Africa Day Memorial Lecture was held on Thursday evening 21 May 2015 at the CR Swart Auditorium. Guest speaker Prof Alcinda Honwana addressed the subject of ‘Youth Protests and Political Change in Africa’.

“Youth now seem able to display what they don’t want, rather than what they do want,” Honwana said in her opening remarks. “Thus, we see the young driven to the streets to protest against regimes.”
 
Honwana shed some light on recent examples of youth protests in Africa that have enjoyed global attention. Looking at the protests in Tunisia (2010), Egypt (2011), Senegal (2012), and Burkina Faso (2014), it is clear that these events in northern and western Africa have inspired others globally. Yet, Honwana stated that, despite these protests, no social economic change has been seen, and has left dissatisfaction with new governments as well.

“Once regimes fall… young activists find themselves more divided, it seems…

“Which leaves the question: Will street protests remain young people’s main mechanism to avert those in power?”

Background on Prof Alcinda Honwana:

Alcinda Honwana is currently Visiting Professor of Anthropology and International Development at the Open University (UK). She was chair in International Development at the Open University, and taught Anthropology at the University Eduardo Mondlane in Maputo, the University of Cape Town in South Africa, and the New School for Social Research in New York. She was programme director at the Social Science Research Council in New York, and worked for the United Nations Office for Children and Armed Conflict. Honwana has written extensively on the links between political conflict and culture, and on the impact of violent conflict on children and youth, conducting research in Mozambique, the Democratic Republic of the Congo, Angola, Colombia, and Sri Lanka. Her latest work has been on youth and social change in Africa, focusing on Mozambique, Senegal, South Africa, and Tunisia.

Honwana’s latest books include:

• Youth and Revolution in Tunisia (2013); 
• Time of Youth: Work, Social Change, and Politics in Africa (2012);
• Child Soldiers in Africa (2006);
• Makers and Breakers: Children and Youth in Postcolonial Africa (2005, co-edited).

Honwana was awarded the prestigious Prince Claus Chair for Development and Equity in the Netherlands in 2007.

 

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