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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Q and A with Prof Hussein Solomon on ‘Terrorism and Counter-Terrorism in Africa’
2015-05-29

 

Political Science lecturer, Prof Hussein Solomon, has launched his latest book, Terrorism and Counter-Terrorism in Africa: fighting insurgency from Al Shabaab, Ansar Dine and Boko Haram, on Wednesday 26 May 2015 at the UFS.

In his book, Solomon talks about the growing terrorist threat in Africa, with the likes of Al Shabaab, Ansar Dine, and Boko Haram exploiting Africa's vulnerabilities to expand their operations. Explaining both the limitations of current counter-terrorist strategies and possible future improvements, this timely study can be appreciated by scholars and practitioners alike.

Q: If you speak of Al Shabaab, Ansar Dine, and Boko Haram expanding operations, do you see possibilities for their expansion even into South Africa, or is expansion mainly focused on northern African countries?
 
A: All three movements are operating out of their respective countries. Al Shabaab has attacked Kenya and Uganda and tried to attack the 2010 Soccer World Cup in South Africa. So yes, there is a danger that they are here and, more importantly, newer groups like ISIS are recruiting in SA already.
 
Q: If the traditional military response is ineffective, what would be a better approach then?

 
A:
What is important is that the force of arms needs to complement the force of ideas. What is being waged is an ideological battle, and, just as the West defeated Communism ideologically in the Cold War, we need to defeat radical Islamism ideologically. In addition, the military response needs to complement the governance and development responses.
 
Q: External players like the US have insufficient knowledge of the context, what would be the knowledge about context necessary for anyone concerned about the terror problem in Africa?
 
A: Allow me to give you some examples. The US trains African militaries to fight terrorist groups, but, when they return to their countries, they stage a coup and topple the civilian government. The US does not seem to understand that arming a predatory military and training them makes them more predatory and brutal, which results in civilians being recruited by terrorists, as happened in Mali. Similarly, the US sent arms to the Somali government, and members of that government sold those arms to Al Shabaab terrorists, the very people they were supposed to fight. So the Americans do not understand the criminalisation of the African state, which undermines good governance and promotes terrorism.

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