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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Prototype film degree introduced for Kovsies
2015-06-11

 

As of 2015, the university’s postgraduate prospectus was modified to include a new Bachelor of Arts Honours in Film and Visual Media course in the Faculty of the Humanities.

A group of eight pilot students are being exposed to basics studies in film history, research, and practical production exercises. The programme’s prototypical nature lies in its inter-disciplinary approach, which means students will integrate film history and theory with individual short film production. 

According to the Programme Committee, “the two parts enrich each other, so students’ practical work is conceptually much stronger, and their written work is more balanced.”

“While other universities locally and abroad do offer film qualifications, the emphasis usually falls on either the history and theory of film, or the making of films.  Our programme is the only one in South Africa (that we know of) that offers this specific kind of integration.”

Chris Vorster, Dr Anthea van Jaarveld, Prof Helene Strauss, and Johanet Kriel are responsible for lecturing, and providing personalised supervision to students. These lecturers form part of a Programme Committee, which also includes Prof Annie van den Oever, Cloete DeBeer, and Martin Rossouw.

The university has built a multi-camera studio, equipped with state-of-the-art equipment, editing facilities, and an intimate movie theatre to facilitate a thorough teaching and learning process.

Rethabile Radebe, one of the students, says she values the teaching approach of the lecturers, highlighting the positive impact of constructive criticism they offer. “My self-confidence is much better so I think, even though they help you academically for you to get your grades correctly, they also help you as a person. When you’ve done well, they don’t forget to tell you.”

This student’s views run parallel to Kriel’s, which are to “help students to perform at their best, and to develop and align our curriculum better for next year,” when an additional seven students are to be accommodated. The university, in collaboration with the University of Groningen in the Netherlands, is modelling the curriculum to ensure holistic film education. 

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