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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Centre for Universal Access and Disability Support HOD selected as prestigious Fulbright scholar
2015-06-24

Hetsie Veitch and Gabriela Schroder
Photo: Valentino Ndaba

Hetsie Veitch, who has served as the Head of the Centre for Universal Access and Disability Support at the university for the past seven years, recently won the prestigious Fulbright Scholarship for studies in the USA. Hetsie has been placed at the renowned Syracuse University in Upstate New York, where she will read for a PhD in Disability Studies in the School of Education.

By focusing on matters of social justice in the pedagogy of higher education, Hetsie will explore the creation of universally accessible learning spaces for students so that she can apply these ideas on her return to South Africa in four years.

Under her leadership, the Unit for Students with Disabilities (USD) was transformed into the Centre for Universal Access and Disability Support (CUADS) in order to reflect new approaches to universal access and universal design.“It is my ultimate goal,” says Hetsie, “to create an institutional culture that includes and welcomes all students with disabilities.”

It is difficult to fully capture the enormous contribution Hetsie has made to the UFS in disability justice, by establishing platforms for students with disabilities that enable them to be appreciated as individuals, and to excel in academic studies.

One of our star students, Gabriela Schröder, also won the prestigious Fulbright Scholarship. Gaby, as she’s called, will be taking up doctoral studies in Biochemistry at a leading university in her field, namely North Carolina State University in Raleigh, North Carolina.

Gaby earned her BSc Honours degree in Biochemistry at the University of the Free State, after also completing her undergraduate studies in Chemistry and Biochemistry at Kovsies.

She participated in the F1 Leadership for Change Programme (Class of 2011) as part of the first-year cohort that went to the University of Vermont. In 2012, she was selected to participate in the elite Stanford Sophomore College Programme with students from Oxford University (UK) and Stanford University in California.

In 2014, Gaby was awarded the Dean's Medal, a distinction which is presented to the best final-year student studying towards a Bachelor’s degree in the Faculty of Natural and Agricultural Sciences. She was also the proud recipient of the Senate Medal, awarded for academic excellence in the achievement of a Bachelor’s degree at the university.

 

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