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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Consumer Science at the UFS awards three PhDs
2015-07-08

Dr Gloria Seiphetlheng, Dr Natasha Cronje, Dr Ismari van der Merwe and Prof Hester Steyn.
Photo: Leonie Bolleurs

For the first time in its history, the Department of Consumer Science in the Faculty of Natural and Agricultural Sciences at the University of the Free State (UFS) earned three doctorates at one graduation ceremony this year. This week three PhDs were awarded to Ismari van der Merwe, Natasha Cronje, and Gloria Seiphetlheng at the Winter Graduation that took place on the Bloemfontein Campus.

Electrochemically-activated water is widely used in the food and other industries, due to its excellent environment-friendly properties. However, it is not used in the textile industry yet, because too little research has been done to determine the possible positive and negative impact it may have on textiles.

With the thesis, The evaluation of catholyte treatment on the colour and tensile properties of dyed cotton, polyester and polyamide 6,6 fabrics,  Dr Cronje, a lecturer in the UFS’s Department of Consumer Science, and Dr Seiphetlheng from the Serowe College of Education in Botswana,  provided major new information with the thesis, Anolyte as an alternative bleach for cotton fabrics. This information is essential when considering the application of catholytes and anolytes in the textile industry.

Electrochemically-activated water divides water in catholytes and anolytes. The anolyte part is used as a disinfectant and bleach. It is not really suitable for domestic use, as it can cause colour loss in coloured textile products. However, it can be used in the hospitality industry where white sheets, towels, etc., are used and washed on a regular basis.

The catholyte part of the water has properties similar to washing powder. It can also be used in the textile industry as washing liquid.

According to Prof Hester Steyn, Head of the Department of Consumer Science and supervisor of all three PhD candidates, this electrochemically-activated water is also very eco-friendly. “It has a short shelf life. If the electrochemically-activated water isn’t utilised, it returns to normal water that wouldn’t harm the environment. No water is therefore lost, and no waste products are released that would contaminate the environment,” she says.

Dr Van der Merwe’s research focused on Degumming Gonometa postica cocoons using environmentally conscious methods. A lecturer in the Department of Consumer Science, she demonstrated that simple and environmentally-friendly methods can be used with great success to procure wild silk from the cocoons of the Gonometa postica worms living in the camel thorn trees found in the Northern Cape and Namibia.

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