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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Dr Mercy Oduyoye receives an honorary doctorate for changing how women are viewed in theology

2015-07-08

Dr Mercy Oduyoye.
Photo: Johan Roux

Dr Mercy Amba Oduyoye received an honorary degree from the UFS Faculty of Theology in acknowledgement of the trailblazing work she has done in the field of African women’s theology. Known as the Mother of African Women’s Theology, Dr Oduyoye is the first black woman in Africa to have received a degree in theology. Ever since then, she has been changing views on gender in theology across the globe. Still at the office at the age of 82, Dr Oduyoye’s life work has centred on two areas: her work with churches, and her work with female theologians.

Women in religion and culture
Following the 2015 Winter Graduation Ceremony on the Bloemfontein Campus, during which Dr Oduyoye received her honorary degree from the University of the Free State (UFS), she presented a lecture on women in religion and culture at the Faculty of Theology. Dr Oduyoye gave a brief overview of her involvement in organisations since the early 1970s to eliminate patriarchal structures in theology, in order to produce a relationship of partnership between women and men. An area that lies especially close to Dr Oduyoye’s heart is that of storytelling, and the use of language. Therefore, a driving force behind her work has been the question: “How do we communicate what we believe as Christians?”

Writing in a way people can understand
This question led Dr Oduyoye on her journey to vernacularise theological language, and it became her mode of writing. “Very seldom will you find the classical or official theological language in my writing, because I’m writing as if I’m speaking to a youth group, a women’s group – or even my grandmother.” In this way, communication became her focal point to present Christianity in such a way that people can understand it, thus rendering it relevant to the situation in Africa.

Changes toward inclusive language
Dr Oduyoye has gone on to author four books and over eighty articles on theology from a feminist perspective. And after toiling for many years, Dr Oduyoye can now see the changes emerging – especially in the US – as Bibles, lectionaries, and hymns are increasingly adopting an inclusive language, giving women a presence and voice within the church.

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