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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

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Leadership and responsible citizenship: key themes at the Global Leadership Summit
2015-07-09

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Leadership and responsible citizenship have been the main topics of discussion at the Global Leadership Summit which started on 5 July at the UFS Campus in Bloemfontein, and will continue until 17 July. More than 103 international delegates from various universities in Asia, the United States, and Europe, as well as 40 student delegates from the University of the Free State, are attending.

Kick-starting the summit talks was Prof Joel Samoff (Stanford University) who led discussions on transformation in institutions around the world. “Transformation is a constantly-changing interaction.  It is not a single objective, but a process, “ he said. This was followed by a robust panel discussion with student leaders of the UFS and those from James Madison University, Mount Holyoke College, and Rutgers University, who described the journey of transformation at their various universities.  “Young people are leading themselves in a different way, the context of the society we live in has changed,” said a UFS Student.

Keynote speaker, Zelda la Grange, gave an account of her experiences and the colourful journey of discovery of a “different” South Africa, working with President Nelson Mandela for 19 years, a journey that is the subject of  her book, “Good Morning Mr Mandela “. Under the theme “Breathing the same air: A metaphor for human solidarity, Prof Pumla Gobodo-Madikizela, Senior Research Professor in Trauma, Forgiveness, and Reconciliation Studies led a talk with Candice Mama, the daughter of slain anti-apartheid activist, Gelnack Masilo Mama, one of the victims of the former hit squad commander, Eugene de Kok. Candice inspired the audience with her philosophy on life and letting go of trauma: “Forgiveness is a process, and one needs to forgive to be able to be liberated from anger and bitterness,” she said.

Dr Lis Lange, Vice Rector: Academic, UFS spoke of citizenship and freedom, focusing on the responsibility that humans have to create ethical, positive, and meaningful interaction in their daily lives and in their societies across the globe.

As part of the programme, delegates will visit the Qwaqwa Campus on 10 July 2015, where they will interact with the leadership of the campus, its staff, and students, and enjoy an arts and cultural experience of the Eastern Free State.  The summit will end with a visit to various sites in Bloemfontein, where delegates will engage in community-based outreach activities in disadvantaged communities around the city. 

UFS to host second Global Leadership Summit

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