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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Kovsie trailblazing track runner sets South African 200 m record

2015-07-16

Photo: IAAF

Wayde van Niekerk became the only South African, and the fourth athlete in the world, to clock sub-20-seconds in a 200 m race on Tuesday 14 July 2015. With this winning time, he became the fourth member of the prestigious quartet, consisting of Michael Johnson, LaShawn Merritt, Isaac Makwala and himself.

The Kovsie gold medallist’s ground-breaking performance saw him beat world-class 200 m specialist and last year's Diamond League race winner, Alonso Edward of Panama. Van Niekerk crossed the finish line half a metre ahead of Edward, who was followed by Fujmitsu Kenji of Japan in the third place.

Van Niekerk's 19.94-time at the Diamond League meeting in Lucerne (Switzerland) set a national record, and improved on his personal best. In 2010, he claimed the World Junior Championship title in Moncton, Canada, by covering 200 m in 21.02 seconds.

Recently, he made history by defeating the London 2012 Olympic Games champion, Kirani James, of Grenada in the Caribbean.

On 4 July 2015, he surged 0.79 seconds ahead of Kirani in his number five lane, becoming the first African to cover 400m in less than 44 seconds. The Kovsie student won the race at 43.96, occupying 10th place on the International Association of Athletics Federations (IAAF) Diamond League all-time list.

Kovsies were still celebrating the gold medalist’s South African record-setting time of 44.24 on 13 June 2015 when he dominated the Diamond League meeting. At the previous race in New York, Van Niekerk improved on his own national record of 44.38. With an impressive dash to the finish line at that particular event, he surpassed Christopher Brown’s 400 m record.

In addition to the country’s record, Van Niekerk made his name as one of the continent’s record-breakers. On 7 June 2015, he broke the 1986 African 300 m record. Van Niekerk replaced Ivorian Gabriel Tiacoh’s best time of 31.74 with a 31.63 championship win at the Birmingham Diamond League meeting. Simultaneously, he bettered Morné Nagel’s 2006 South African national record.

Following his outstanding performance, he was positioned in 10th place on the world list in the men’s 300 m.

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