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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Moving towards creating a more accessible UFS for mobility-impaired students
2015-07-21


Centre for Universal Access and Disability Support’s logo for persons with mobility impairments.
Design: Karoo Republic


Hi, my name is Jackson, and I am a wheelchair user following an accident that left me paralysed.

We often take for granted the ability to navigate obstacles, and to move readily from place to place. Few people have to worry about mobility on campus, but for students with mobility impairments, it presents many challenges that few of us are aware of.

 

The biggest struggle for students with mobility impairments is often encountered in the lecture room/hall. Once they arrive at the class (often struggling to get there on time), their next challenge might be entering the classroom and finding a suitable place where they can sit comfortably. As it is, there are only a few loose tables in most lecture halls. Consequently, the students have to sit through the lecture taking notes and working with their laptops resting on their laps. Obviously, this is uncomfortable and not conducive to their learning process.

 

When students have limited hand function, the result is that they write more slowly and with difficulty. However, the UFS does offer assistance from scribes, adapted computer hardware/software, assistive devices, and/or modified furniture. Such adaptations can be arranged by the Centre for Universal Access and Disability Support (CUADS), which boasts an official test and examination venue where students with mobility impairments can proceed with their tests and exams if they prefer.

 

Students with Cerebral Palsy may experience difficulties with quick, sudden physical movements, and delayed processing of information. Stressful circumstances can result in their experiencing difficulty when having to write or process information quickly enough during test and examination situations. The Extra Time Panel, in collaboration with Student Counselling and Development, determines the time concession for those students with mobility impairments who have such needs.  

 

The importance of accessible parking spaces exclusively designated for wheelchair users not only involves such places being closer to a building entrance but also wide enough for a wheelchair user to get in and out of a vehicle safely.

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