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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Training in critical medical skills receives preference at the UFS
2015-07-24

The UFS bought a new simulator for surgeons to learn how to perform laparoscopic operations. During the launch of the simulator, Dr Mathys Labuschagne (left), Head of the Clinical Simulation and Skills Unit, illustrates to Prof Gert van Zyl, Dean of the faculty, how the simulator works.
Photo: Rene-Jean van der Berg

The Clinical Simulation and Skills Unit in the University of the Free State (UFS) Faculty of Health Sciences purchased a new laparoscopic simulator for R1.2 million recently. The simulator will be used to teach postgraduate medical students how to perform laparoscopic surgery. The UFS is currently the only university in the country, and one of only two institutions in South Africa, that own such a simulator.

The Lapsim simulator, from Surgical Science in Sweden, is a highly sophisticated computerised tool for the training and improvement of laparoscopic surgical skills in postgraduate students within the surgical disciplines.

“The purpose of a simulator is not to replace training on patients, but to help registrars in acquiring basic laparoscopic surgical skills,” says Dr Mathys Labuschagne, Head of the Clinical Simulation and Skills Unit.

These skills include depth perception, hand-eye-coordination, instrument handling, precision and speed, which are essential before operations can be performed on patients.

Prof Gert van Zyl, Dean of the Faculty of Health Sciences, says this simulator is very important for the UFS to train registrars more effectively in theatre work.

“Not only registrars will benefit from this, but qualified surgeons may also make use of it to improve their skills.”

The simulator is pre-programmed for different medical conditions that laparoscopic surgery is traditionally used for. Programmes can be selected for procedures such as sterilisation, cholecystectomy (gall bladder removal), endometriosis, etc. The simulator even makes it possible simply to practise eye-hand coordination, and to apply stitches internally.

Watch the short video explaining more about the Lapsim simulator.

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