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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Food insecurity at university campuses a growing threat
2015-07-28

Food insecurity on university campuses in South Africa has come to the fore as one of the more pressing subjects that needs to be tackled to ensure the continuing education of disadvantaged students across the country.

On Friday 14 August 2015, the University of the Free State will host the first higher education colloquium on food insecurity on university campuses.  The one-day colloquium will take place during the Arts and Social Justice Week, in collaboration with the UFS’s Institute for Reconciliation and Social Justice Best practices will be shared, exploring the available research on student food insecurity at institutions of higher education.

Food insecurity has emerged as a pressing social justice issue affecting students countrywide. Action needs to be taken to promote the academic success of students, who will ultimately contribute to the country’s economic growth. One of the primary focus areas of the colloquium will be to establish a common practice to address this need.  Universities leaders, staff from wellness and social work departments, and SRC members from across the country who have been invited, and are expected to attend, are the University of Pretoria, the Tshwane University of Technology, North West University, UNISA, and the Central University of Technology.

Professor Jonathan Jansen will participate in a panel discussion alongside Ruda Landman and Prof Edelweiss Wentzel-Viljoen (HPCSA). This promises to be an inspiring meaningful dialogue, by asking the difficult question:  How do we change the food insecurity situation at universities?

The University of the Free State is currently the country’s leading university in addressing food insecurity on all its campuses through its flagship No Student Hungry Bursary programme, which has funded more than 500 students since it was established in 2011.

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