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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Colloquium probes solutions for student hunger
2015-08-03

While higher education is deemed necessary for future financial security, high tuition and accommodation fees, as well as increasing food prices, are forcing students to drop out of university.

Dr Louise van den Berg, Senior Lecturer and Researcher at the University of the Free State (UFS), says university campuses are not often associated with food insecurity, but, due to the increase in first-generation students and students of low-income households receiving tertiary education, student hunger at some of the country’s prominent campuses needs urgent intervention.

On 14 August 2015, the University of the Free State (UFS) will host the first higher education colloquium in the country, on food insecurity on university campuses.  Best practices will be shared, exploring the available research on student food insecurity at institutions of higher education. Programme of the colloquium.

A study by the UFS Department of Nutrition and Dietetics found that as many as 60% of students on our campuses were food-insecure, and experienced hunger. This study was the first of its kind in South Africa, and led to the No Student Hungry Bursary Programme (NSH) at the UFS. The level of severe food insecurity reported was much higher than that reported in Australia, New York, and Hawaii by the only other three studies that have been done.

“The UFS is not the only campus struggling with food insecurity,” say Dr Van den Bergh.

“The general misconception is that a student, having money for studies, should have money for food. Funders need to reassess bursaries, keeping issues such as food insecurity in mind, and not just focusing on tuition.”

Bursaries, especially government funding, became easily available to bridge the inequality gap in our country.

“Although bursaries pay for tuition, many students have no resources for food. Universities currently have a 50% drop-out rate currently, with many students dropping out due to poverty.”

 

What is NSH?

 

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