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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Universal Access and Universal Design approach align UFS with international standards
2015-08-11

Making mobility for students with disabilities easier, First Car Rental representatives hand over the brand new Toyota Quantum to Hestie Veitch, Head of CUADS.
Photo: Valentino Ndaba

The Centre for Universal Access and Disability Support (CUADS) launched successfully on 24 July 2015. The objective was “to make more people on campus and from the greater UFS community aware of the services that we provide, and to spread the word about Universal Access.”

“Since the center was founded in 2001, structural and systematic developments have occurred in order to create a welcoming and accessible learning environment that grants students opportunities to be successful in their academic endeavours. Thus, the Unit for Students with Disabilities (USD) has evolved into the CUADS in support of the social model of disability,” said Hetsie Veitch, former Head of the Centre.

Implementing the Universal Access and Universal Design approach has aligned the University of the Free State (UFS) with international standards.

Mingling with the experts

Vendors from across the country displayed their products, and offered demonstrations of functional gadgets and essentials at the event.

Marita Erlank from Sensory Solutions demonstrated how to operate the specialised scanner, which converts printed material to enlarged electronic text and audio, using the Open Book software.

Representing the university’s Sign Language Student Association were Carla Bester, Elrie de Toit and Tebogo Chabangu. To support Deaf Awareness Month (September), theyplan to dedicate a weekto facilitating free workshops for students not registered for the module.

David Greenland and his teamwere also present as part of a Wheelchair Appreciation Month campaign. On 1 September2015,the group of students will raise awareness of the daily challenges faced by mobility-impaired persons by spending the day in wheelchairs.

The day ended on a festive note, by courtesy of the First Car Hire Rental Company. A brand-new Toyota Quantum was handed over as a long-term rental, enabling students of the university to travel between campuses free of charge.

CUADS aims to continue transforming the UFS into a universally-accessible environment by collaborating with internal and external stakeholders. The launch marks a significant step towards Universal Access and Design.

 

 

 

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