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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

TEDxUFS conference - the highlight of the university’s innovative calendar
2015-08-11


Mmusi Maimane, leader of the Democratic Alliance with co-organisers of TEDxUFS Bonginkosi Leeuw and Lerothodi Molete after his inspirational talk at the event.
Photo: Curtis Nhlamulo Mashimbye

This year’s TEDxUFS speaker lineup persuaded the audience unanimously to question the nature of reality. The Albert Wessels Auditorium on the Bloemfontein Campus was packed with about 200 attendees on Saturday 1 August 2015.

Speakers shared a multiplicity of profound theories and inquisitions, challenging society in general to think out of the box. Melody Mentz, Gil Oved, Ricardo Peach, Pamela Nomvete, Pepe Marais, Mmusi Maimane, Brian Kally, Pieter Geldenhuys, Philippa Tumubweinee, Gareth Cliff, and Angelo Mockie took on to the stage to tackle multidisciplinary concepts as part of the broad ‘Ask Why’ theme.

Innovation mouthpieces share their worldview

Pieter Geldenhuys, the internationally-renowned futurist and Director of the Institute for Technology Strategy, and Innovation proposed that we change our mindsets by neglecting predictability. “We need to look at different models to understand the world around us,” he said. He challenged the linear and familiar ways humans make sense of the universe.

Speaking to the dire need for transformation, Philippa Tumubweinee suggested that university spaces merge with the communities they serve in terms of policies, social atmosphere, and physical structure. Tumubweinee is a senior Lecturer at the Department of Architecture at our university, and co-Founder and Director of Izuba In Africa architects.

“Only we can give permission to be intimidated; so don’t give in,” said Brian Kally, the CEO of Arrow Logistics (Pty) Ltd. Kally underscored the power of believing in our individual ideas.

Guidelines from TEDxUFS organisers

Bonginkosi Leeuw: “If you take your brainchild and implement it, and make it a reality, that’s when you can achieve great things, not before that.”

Lerothodi Molete: “You should ask questions; the moment you ask the question you will understand more.”

Real-time social media feedback

These are some of the comments audience members published on Twitter at the event:

IG: mispertanzy ?@MiesperTanzy  Aug 1

A huge shout-out to @TEDxUFS for hosting such a great conference!The team has really made the event an unmissable one on the UFS calendar.

Celebrabitur? ?@HatsuMphatsoe  Aug 1

Proximity that allows us to experience our broader society. Truly engaged by Philippa Tumbweinee's talk! @TEDxUFS

TEDxJohannesburg ?@TEDxJoburg  Aug 1

A big shoutout to @TEDxUFS from for a fantastic event. Wish we were there.

RicardoPeach ?@ricardopeach  Aug 1

Africa is rich with potential  #TEDXUFS @MmusiMaimane Yes!

 

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