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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Out of the ordinary lunch with Prof Jansen
2015-08-17

Prof Jansen and the twins pose for pictures after enjoying a laugh and chat at the lunch event.

Numerous sets of twins and a set of triplets were entertained by, and enjoyed lunch with, the Vice-Chancellor and Rector of the university, Prof Jonathan Jansen.  Wednesday 12 August 2015 marked an extraordinary day in the Kovsie history book.

The Reitz Hall in the Centenary complex was filled with echoes of laughter as Prof Jansen told “twin jokes” he had Googled earlier for the occasion. Save for the humour, he said that twins and triplets represent a unique bond.  “After all, we should be striving for a way of being together,” he said, speaking about the quest for national solidarity.

Sitting in groups of six, and after the introductions, the duos and trio were soon engaged in conversation.

Anita and Mikita Miza, who were sharing a table with Marike and Ilna Marais, told stories from their childhood.

“We did not realise that we were twins until we were in grade one,” said Anita, who is studying the same course as her sister. Mikita is in the second year of her BSoc Science degree, while her twin is a year ahead. She had to remain in Mtata, their hometown, for a year while Anita began her first year. “It was the longest year of my life,” said Mikita.

Marike and Ilna are first years in Physiotherapy and Optometry, respectively. When asked by Prof Jansen what they never share, the non-identical twins were quick to reply: “clothes,” although they still share a room. When they were in high school, fellow learners struggled to believe that Marike and Ilna are twins, because of their distinctly different looks.

The lunch united strangers, who have a unique common bond, and acted as a platform to tell interesting stories that are seldom heard.

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