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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Social work students off to Sweden on exchange programme
2015-08-17


Excited about the prospects of studying in Sweden, Letttie and Moratoe already have their bags packed. Photo: Valentino Ndaba

In 2011 the university signed an exchange programme agreement with Jönköping University (JU), in Sweden. Since the inception of the contract the UFS Department of Social Work has been able to send two second year students to the guest university for a semester annually while also hosting students from JU.

 

The UFS is one of only 350 partner universities that JU co-operates with on an international level. The university that describes itself as “the most international university on Sweden” welcomes 714 exchanged students annually. This year, their School of Health and Welfare will host two of our Social work students, Moratoe Tshabalala and Lettie Mohoko; who are the fourth duo to take this unique opportunity.

These Kovsies will join the JU from 17 August-20 December 2015. By focusing on Swedish Social work and welfare policy, participation and inclusion, and Old-age care, they intend to use the learning experience to influence our country’s welfare system.

Growing up in Wesselsbron - a small town in the Free State, Lettie has always been passionate about working with people and having a positive impact on their lives. She sees the exchange programme as an opportunity to gain an international perspective which will provide more skills, hence improving her community engagement.

Moratoe, who is from the small town of Senekal, echoed similar sentiments, adding that she is interested in the distinctiveness of Sweden’s social welfare system, which offers free education, where old people get free care from the government, and children get incentives to attend school.

Lettie and Moratoe also volunteer as representatives of the UFS at ENGO Family Care, a non-profit organisation in Bloemfontein.

Dr Anneline Keet, Head of the UFS Social Work Department, believes that the exchange experience enhances the students’ critical thinking, and facilitates their ability to engage with different social welfare systems. While only two students are able to experience the full exchange annually, the rest of the students also benefit from the discussions taking place in class where students from the guest university (JU) join them for a semester.

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